Xochitl De la Rosa Reyna
Humberto Martínez Montoya
Victoria Valerio Castrellón
Ana M. Sifuentes Rincón
Manuel Parra Bracamonte
Williams Arellano Vera
ABSTRACT
The IGF1 gene (insulin-like growth factor 1) is a candidate gene for marker-assisted selection strategies. A SNP in the promoter region (IGF1/Sna BI) has been reported and associated with production traits in several cattle breeds. Here, we report its allelic frequencies evaluated in Charolais and Beefmaster breeds, and confirm its association with three growth traits: weaning weight (PD), weaning weight adjusted to 210 days (P210) and preweaning weight gain (GPD) in Charolais breed. In addition, we designed a strategy to search in these breeds for a new polymorphism in four coding regions of the gene. A C/A transversion was detected in intron 4, but it did not show an association with the growth traits tested.
The SNP (IGF1/SnaBI), is proposed as a potential selection marker in Mexican Charolais cattle, the validation of its association with PD, P210 and GDP, could complement the genetic evaluations of this breed through marker-assisted management strategies. The characterization of the gene IGF1 in Mexican populations of Beefmaster and Charolais cattle permitted the identification of a new SNP in this gene, which should be the subject of future studies to determine its role as a molecular marker.
Ya en Genetics and Molecular Research Evolution and Technology.
http://www.funpecrp.com.br/gmr2008b/index.asp
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